Converted MCF7 RR cells biochemically similar to RR cells. RU and RR
We propose that exosomes secreted by radioresistant (RR) cells may be able to disseminate the RR phenotype throughout the tumour.
RR cells exhibit higher CD44 expression, enhanced capacities for colony
Molecularly, a secretory form of acid sphingomyelinase is translocated to the extracellular leaflet of the cell membrane and transforms sphingomyelin into the pro-apoptotic protein ceramide via enzymatic hydrolysis [27].
Oxidative stress induces the conversion of RU to RR cells. a RU cells
The aim of the present study was to determine if two cell lines, one radiosensitive (RS) and another radioresistant (RR), showed differences in DNA repair capacity, cell viability, cell.
Premature mitosis kill RR cells and blocking cytokinesis lead MNGCs to
Sickle cell disease can cause severe pain and organ damage, life-threatening disabilities, and early death. Nicole Verdun, M.D., is the Office of Therapeutic Products director in the Food and Drug.
RU cells converted to RR cells upon H 2 O 2 challenge. A . RU cells
SCC9-RR and CAL27-RR cells had a significantly increased SF2 and D 0 values (the D 0 of SCC9 and SCC9-RR cells did not show statistical differences), and significantly decreased α and α/β parameters in comparison to parental cells (Supplementary material 1, Table 2). Flow cytometry analysis was performed on the parent and radioresistant.
The Wnt/βcatenin pathway contributes to the high MYC expression in RR
Irradiation protocol to establish RR-strains in LDR and HDR systems. Cells were seeded at 1 × 10 6 cells/60 mm dish 1 d before irradiation in serum-free medium DF6F. In the LDR system, dishes were placed in a 2.2-Gy/d incubator, which has a dose rate of 1.52 mGy/min and continuously irradiated for 4 d/wk. Cells were passaged on day six with the above cell density, and the process was.
Exosomes isolated from RR cells enhanced sphereforming ability
Radioresistant cell lines were established by exposing MDA-MB-231, MCF-7 and ZR-751 parental cells to increasing weekly doses of radiation. The development of radioresistance was evaluated through proliferation and colony formation assays. Phenotypic characterisation included migration and invasion assays and immunohistochemistry.
Proteasomes indirectly regulate RR cell survival via the NFkB
Cells dissociated from the tumor were regarded as radioresistant U87MG cells (hereafter referred to as U87MG-RR cells). Figure 1 DGKB is downregulated in radioresistant GBM cells and radiation reduces DGKB expression. Show full caption (A) A scheme illustrating the establishment of U87MG-RR cells through repeated xenograft and irradiation..
Converted RR cells share similar biochemical features with RR cells. a
We focused on reversal reactions (RRs), a dynamic process whereby some patients with disseminated lepromatous leprosy (L-lep) transition toward self-limiting tuberculoid leprosy (T-lep), mounting.
MAPK and PI3K pathway activity in the canine and human parental and
Rhesus (Rh) blood group. 1940 Landsteiner and Wiener reported an antibody that reacted with about 85% of human red cell samples. It was supposed that anti-Rh was the specificity causing the "intragroup" incompatibilities observed. 1941 Levine found in over 90% of erythroblastosis fetalis cases, the mother was Rh-negative and the.
RR cells exhibit higher level of Myc and transcription activity
Explanation of these findings, including resistance mechanisms to anti-CD19 CAR T cells in R/R MCL remain to be fully determined. 78 All 6 R/R MCL patients with aberrant TP53 who were efficacy-evaluable in ZUMA-2 achieved CR with CAR T-cell therapy. 78 Given the difference in EMA and FDA labels, KTE-X19 may be used in a slightly different.
RR cells show different migration and invasion capacities. Download
The HCC1806-RR is a new model that expresses bona fide markers of B-TNBC and traceable markers for quantifying metastases. Combination of bevacizumab with nab-paclitaxel significantly improved the outcome, suggesting that this approach can apply to human patients with B-TNBC.
RR cells exhibit higher level of Myc and transcription activity
The Rh blood group system is a complex set of red blood cell surface proteins that most likely function to maintain the integrity of the cell membrane. As of May 2016, we know of at least fifty Rh antigens according to the International Society for Blood Transfusion, but we spend most of our time worrying about only five of them.
Diagram showing that CaPRR cells are associated with the induction of
Since most D-negative people have either the rr genotype (most common) or the rr' genotype, the vast majority of D-negative ("Rh-negative") individuals are f-positive. People who lack the f antigen are almost always D-positive, with genotypes like R 1 R 1, R 1 R 2, or R 2 R 2 (to name a few). Those who lack the antigen, not surprisingly.
Converted RR cells acquired phenotypes of RR cells. A . RU and RR cells
RMS-RR cells were compared to parental isogenic counterpart (RMS-PR) and studied following the radiobiological concept of the "6Rs", which stand for repair, redistribution, repopulation, reoxygenation, intrinsic radioresistance and radio-immuno-biology. RMS-RR cell lines, characterized by a more aggressive and in vitro pro-metastatic.
The 3′ RR interacts via looping with many different target Igh
Radioresistant (RR) cells are poor prognostic factors for tumor recurrence and metastasis after radiotherapy. The hyaluronan (HA) synthesis inhibitor, 4-methylumbelliferone (4-MU), shows anti-tumor and anti-metastatic effects through suppressing HA synthase (HAS) expression in various cancer cells. We previously reported that the administration of 4-MU with X-ray irradiation enhanced.